In Vivo Messenger RNA Introduction into the Central Nervous System Using Polyplex Nanomicelle
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چکیده
منابع مشابه
In Vivo Messenger RNA Introduction into the Central Nervous System Using Polyplex Nanomicelle
Messenger RNA (mRNA) introduction is a promising approach to produce therapeutic proteins and peptides without any risk of insertion mutagenesis into the host genome. However, it is difficult to introduce mRNA in vivo mainly because of the instability of mRNA under physiological conditions and its strong immunogenicity through the recognition by Toll-like receptors (TLRs). We used a novel carri...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2013
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0056220